3,4-디히드로-3-옥소-2H-1,2,4-벤조치아디아진-1,1-디옥사이드 유도체의 합성 및 세포 독성

• 영문명: Synthesis and Cytotoxic Properties of 3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-1,1-dioxides
• 발행기관: 대한약학회
• 저자명: 박혜영(Hea Young Park) 한윤정(Yun Jong Han) 이정옥(Jeong Ok Lee)
• 간행물 정보: 『약학회지』제39권 제6호 (1995년), 631~635쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

A series of 3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-l,l,dioxides with cytotoxic activity against human solid tumors is described. Synthesized compounds showed mild but broad spectrum cytotoxicity in vitro. The lipophilic substituents like alkyl, alkoxy and chloro on benzene ring increased the activity. Also hydrophobic group on 3 or 4 position of benzothiadiazine was important for the activity