Ginkgolide B 및 ginkgoflavonoids 의 in vitro 와 ex vivo 및 임상에서의 항혈전 작용

• 영문명: Anti-platelet Aggregation Effect of Ginkgolide B and Ginkgoflavonoids, Extracted from Ginkgo biloba, in Vitro, ex Vivo and in Clinic.
• 발행기관: 대한약학회
• 저자명: 권광일(Kwang Il Kwon) 이영신(Young Sin Lee)
• 간행물 정보: 『약학회지』제39권 제3호 (1995년), 337~345쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

The effects of ginkgolides(natural mixture of ginkgolides, ginkgolide B, ginkgolide C) and flavonoids(quercetin, kaempferol. myricetin), extracted from Ginkgo biloba, on ADP and PAF-induced platelet aggregation in vitro and ex vivo were investigated. In these experiments, both of ginkgolides and ginkgoflavonoids did not affect the ADP(5mcM) induced platelet aggregation in vitro. The IC50 value on PAF (0.3mcM) induced platelet aggregation were 2.52mcM (ginkgolide B) and 6.35mcM (natural mixture of ginkgolides) and 2.80mcM (mixture of ginkgolide B and quercetin). Oral administration of ginkgolide B(1 and 3mg/kg) and quercetin(3 and 9mg/kg) to rabbits inhibited ex vivo PAF induced platelet aggregation in a dose-dependent manner. Ginkomin-F tablets administered to the diabetic patients showed inhibitory activities on the ADP and PAF induced platelet aggregation in a dose and time dependent manner.