신규 퀴놀론계 항생물질 DWQ-013의 흰쥐 및 생쥐에서의 체내동태

• 영문명: Pharmacokinetic Study on DWQ-013, a New Quinolone, in Rats and Mice
• 발행기관: 대한약학회
• 저자명: 조재열(Jae Youl Cho) 남권호(Kweon Ho Nam) 김동오(Dong O Kim) 이종완(Jong Wan Lee) 박남준(Nam Joon park) 강영숙(Young Sook Kang) 유영효(Young Hyo Yu) 이재욱(Jae wook Lee)
• 간행물 정보: 『약학회지』제39권 제3호 (1995년), 223~230쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

The pharmacokinetics and tissue distribution of DWQ-013, a new quinolone, were examined in rats and mice following a single intravenous and oral administration. DWQ-013 in plasma and urine was determined by both HPLC and microbiological assay. The plasma concentration of the drug declined biexpohentially. The terminal half life of the drug was 1.11 +/- 0.14 hour after intravenous dosing. The volume of distribution at terminal elimination phase(Vdbeta) and total clearance of the drug were 1.29 +/- 0.15l/kg and 0.78 +/- 0.09 l/h/kg. The bioavailability of DWQ-013 after oral administration was 56.0%(HPLC) and 77.2%(bioassay), respectively. Twelve-hour urinary recovery of drug was measured by HPLC and bioassay to 0.035 +/- 0.009% and 4.71 +/- 0.66% after oral dosing, to 0.055 +/- 0.014% and 7.65 +/- 1.53% after intravenous dosing, which may indicate the presence of biologically active metabolites. Binding of the drug to plasma proteins ranged from 97%-99% at various concentrations. The drug was highly distributed in order of liver, kidney and lung after 1.5 hours in mice.