신규 Carbapenem 유도체 CRB 529, 535, 538, 545, 550의 시험관내 항균력 평가

• 영문명: In Vitro Antibacterial Activities of CRB 529, 535, 538, 545 and 550, A New Carbapenem Derivatives
• 발행기관: 대한약학회
• 저자명: 민관기(Kwan Kee Min) 김준겸(Joon Kyum Kim) 이홍우(Hong Woo Lee) 김정우(Jeong Woo Kim)
• 간행물 정보: 『약학회지』제39권 제3호 (1995년), 215~222쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

The in vitro antibacterial activities of new carbapenem, CRB 529, 535, 538. 545 and 550 with meropenem and imipenem were compared. CRB 529, 535, 538, 545 and 550 proved to have a broad antibacterial spectrum. Its in vitro activity against standard 20 strains was almost the same as that of imipenem and slightly higher than that of meropenem. However, against clinical isolated P. aeruginosa, CRB 529. 535, 538, 545 and 550 showed significantly higher activity than imipenem, and also CRB 529, 535, 538, 545 and 550 showed almost the same activity than imipenem and meropenem against 82 clinical isolated strains including S. aureus (MRSA), S. aureus (MSSA), E. faecalis, E. facium, E. coli, P. aeruginosa, K. pneumonia, P. mirabiris, P. stuartii, M. morganii, C. freundii, E. cloacae, S. marcescens and A. calcoaceticus var. anitratus. The stability of CRB 529, 535, 538, 545 and 550 against porcine renal dehydropeptidase-I (DHP-I) was 10 folds higher than that of imipenem and was 3 folds higher than that of meropenem.