새로운 beta-lactam계 항생물질 개발을 위한 검정용 균주의 개발

• 영문명: Selection of Clinically Isolated Strains for Evaluation of the Newly Synthesized Antibiotics
• 발행기관: 대한약학회
• 저자명: 김대진(Dae Jin Kim) 최금화(Keum Hwa Choi) 김숙경(Sook Kyung Kim) 최성숙(Sung Sook Choi) 김병각(Byung Kak Kim) 강창율(Chang Yuil Kang) 최응칠(Eung Chil Choi)
• 간행물 정보: 『약학회지』제39권 제2호 (1995년), 131~136쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.04.28

영문 초록

Clinically isolated bacterial strains resistant to almost of all the clinically superior beta-lactam antibiotics can be used to screen the promising ones among the newly synthesized beta-lactam antibiotics. To select the resistant strains, the susceptibility of 389 strains of S. aureus, 144 strains of coagulase negative staphylococci, 509 strains of E. coli, 115 strains of E. cloacae and 187 strains of P. aeruginosa to methicillin, ampicillin, piperacillin and gentamicin was determined. The susceptibility of 19 bacterial strains selected through the first screening to cefixime, cefotiam, cefotaxime, flomoxef, cepfirome, cefdnir, SCE-2787, panipenem and imipenem was determined. Four strains of S. aureus finally selected have high degree of resistance to almost of all bata-lactam antibiotics used and also produce beta-lactamases. These 4 strains of S. aurues can be used to screen effectively the promising beta-lactam antibiotics among the numerous numbers of the newly synthesized beta-lactam antibiotics.