다제내성 황색포도상구균이 가지고 있는 테트라사이클린 내성 플라스미드의 동정

• 영문명: Characterization of Tetracycline Resistance Plasmid of Multidrug-resistant Staphylococcus aureus
• 발행기관: 대한약학회
• 저자명: 이대운(Dae Woon Lee) 문경호(Kyung Ho Moon)
• 간행물 정보: 『약학회지』제39권 제1호 (1995년), 6~9쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.02.28

영문 초록

The clinical isolate Staphylococcus aureus SA2 had four kinds of plasmids and was resistant to ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin, kanamycin, methicillin, streptomycin, tetracycline and tobramycin. Transformation experiment demonstrated that 4.44kb plasmid(pKH6) encoded resistance to tetracycline. The cleavage map of pKH6 was determined by restriction enzyme mapping techniques. The cleavage map is given for EcoRV, HindIII, HpaI, HpaII, KpnI and XbaI. Restriction endonucleases BamHI, BglI, BglII, BstEII, EcoRI, HaeIII, PstI, PvuII, SalI, SmaI, and XhoI have no site on this plasmid. The restriction map revealed extensive structural homology between pKH6 and pT181.