딜티아젬의 개 신장기능에 미치는 영향

• 영문명: Effect of Diltiazem on Renal Function in the Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 임광남(Kwang Nam Lim)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 568~578쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

This study was performed in order to investigate the effect of diltiazem, which is a Ca2+ channel blocker of benzothiazepine derivatives, on renal function in the dog. Diltiazem, when infused into the vein or carotid artery, produced the antidiuresis accompanied with the decreased excretion rates of sodium and potassium in urine(ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules(RNa, RK). Diltiazem, when infused into a renal artery, exhibited the diuresis along with the increased renal plasma flow(RPF), osmolar clearance(Cosm), ENa and EK, and decreased RNa and RK in only infused kidney. Above results suggest that diltiazem possess both antidiuretic action through central action and diuretic action by direct inhibition of electrolytes reabsorption rates in renal tubules, mainly distal tubule.

키워드

Diltiazem antidiuretic action diuretic action dog.