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• 영문명: Antiinflammatory Activity of Flubiprofen Gel on Carrageenan-induced Edema
• 발행기관: 대한약학회
• 저자명: 길형준(Hyung Jun Gil) 이장원(Jang Won Lee) 지상철(Sang Cheol Chi)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 525~529쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

Antiinflammatory activity of an 1% flurbiprofen transdermal gel was evaluated using the carageenan-induced rat paw edema method. The application of 50mg of the gel on the rat hind paw, at various time intervals from 0 to 24 hrs before the carrageenan injection, significantly inhibited edema formation in all groups of dosed rats, indicating that the antiinflammatory activity was maintained up to 24 hrs after the transdermal application of the 1% flurbiprofen gel. The topical ED50 of flurbiprofen in the gel was 1.0mg/kg, whereas the oral ED50 of the drug in a suspension was 1.7mg/kg.

키워드

Flurbiprofen Gel Antiinflammatory activity Carrageenan.