7-[(3-메틸티오 또는 3-메틸티오메틸)-3-피롤리닐]퀴놀론-3-카르복실산의 합성과 항균작용

• 영문명: Synthesis and Antimicrobial Activity of 7-[(3-Methylthio or 3-Methylthiomethyl)-3-pyrrolinyl]quinolone-3-carboxylic Acids
• 발행기관: 대한약학회
• 저자명: 이재욱(Jae Wook Lee) 손호정(Ho Jung Son) 이규삼(Kyu Sam Lee) 유영효(Young Hyo Yu) 김대영(Dae Young Kim)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 520~524쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

A number of 7-[(3-methylthio or methylthiomethyl)-3-pyrrolinyl]quinolone-3-carboxylic acids were synthesized by condensation of 7-fluoro substituted quinolone-3-carboxylic acid with 3-methylthio-3-pyrroline or 3-methylthiomethyl-3-pyrroline. The in vitro antimicrobial activity of them were tested against twenty species of Gram-positive or Gram-negative microorganisms. It showed remarkable antibacterial activity, particularly against Gram-positive microorganisms. Among those 1-cyclopropyl-6,8-difluoro-7-[(3-methylthiomethyl)-3-pyrrolinyl]-l,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12a) and 1-cyclopropyl-6-fluoro-8-chloro-7-[(3-methylthiomethyl)-3-pyrrolinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12b) showed the most potent in vitro antibacterial activity.

키워드

3-methylthiomethyl-3-pyrroline 3-methylthio-3-pyrroline quinolone antibacterial antibacterial activity.