Acetylcholinesterase에 대한 (1,3-Dioxolan-2-yl 및 Dioxan-2-yl)methylaminium 유도체의 저해 작용

• 영문명: Inhibitory Activity of (1,3-Dioxolan-2-yl and Dioxan-2-yl)methylaminium Derivatives against Acetylcholinesterase
• 발행기관: 대한약학회
• 저자명: 피택산(Taek San Phi) 김윤배(Yun Bae Kim) 김지천(Jee Cheon Kim) 조영(Young Cho) 석대은(Dai Eun Sok) 차승희(Seung Hee Cha) 서원준(Won Jun Seo)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 511~515쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

We examined the inhibitory activity of (1,3-dioxolan-2-yl and 1,3-dioxan-2-yl)methylaminium derivatives(A; 1-8) against acetylcholinesterase. Derivatives of six-membered 1,3-dioxane exhibited more potent inhibitory effect than corresponding 5-membered 1,3-dioxolanes. The presence of methyl group at C4 position of dioxane ring was effective to increase the inhibitory potency of heterocyclic analogues. The activity of N-phenacyl-aminiums was greater than that of N,N,N-trimethyl-aminiums. In general, the terminal methyl group on 1,3-dioxane ring and the phenacyl group in ammonium compound A were assumed to be important factors to enhance the inhibitory action.

키워드

(4-Methyl-l,3-dioxan-2-yl)methylaminiuin terminal methyl group anisotropy acetylcholinesterase.