항염증제로서 2-아릴-5-벤즈옥사졸프로피온산 유도체의 합성

• 영문명: Synthesis of 2-Aryl-5-benzoxazolepropionic Acid Derivatives as Antiinflammatory Agent
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 곽용실(Yong Sil Kowak) 금덕현(Dek Hyun Geum) 손병화(Byeng Wha Son)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 504~510쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

A facile synthesis of 2-aryl-5-benzoxazolepropionic acid derivatives(10a-d), which are potent antiinflammatory agent, is reported. Methyl alpha-(p-hydroxyphenyl)propionate(5) was prepared from Friedel-Crafts reaction of isopropoxy benzene with methyl alpha-chloro-alpha-(methylthio) acetate(1), followed by desulfurization, methylation and clevage of ether bond. Compounds(10a-d) were made from(5) by a sequence of nitration, reduction, formation of benzoxazole ring, and hydrolysis in good yields, respectively.

키워드

2-AryI-5-benzoxazolepropionic acid Antiiflammatory agents Methyl a-(p-hydroxyphenyOpropionate Friedel-Crafts reaction Metyl a-chloro-a-(methylthio)acetate Desulfurization Formation of benzoxazole ring.