흰쥐의 급만성궤양모델에서 제산제와 Aceglutamide aluminium의 병용효과

• 영문명: Effect of Antacids, Aceglutamide Aluminium or Their Combination on Acute and Chronic Ulcer Models in Rats
• 발행기관: 대한약학회
• 저자명: 장병수(Byeong Su Jang) 염제호(Je Ho Yeom) 강진석(Jin Suk Kang) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park) 김운자(Woon Ja Kim) 천선아(Sun A Chun) 김상미(Sang Mee Kim) 이은방(Eun Bang Lee)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 496~503쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

The combined products of antacids(AM) composed of aluminium hydroxide, magnesium hydroxide, and simethicone with a ratio bf 1:1:0.1 and aceglutamide aluminium(AGA) were assayed for the antiulcer activity. The effect of the antacids(AM) in concurrent treatment with AGA was studied in acute gastric lesion induced by Shay''s method, stress, ethanol, and indomethacin, in chronic gastric ulcers induced by acetic acid, and in duodenal ulcer induced by mepirizole. In all experimental models, the combined treatment of AM and AGA in the ratio of 2.3:1 showed significant potentiation in inhibition against acute gastric and duodenal ulcer and revealed a significant potentiation of the healing of chronic gastric ulcer.

키워드

Antacids[A](0H)3 Mg(0H)2 simethicone] Aceglutamide aluminium Gastric ulcer Duodenal ulcer.