담즙산류과 베타-시이클로덱스트린간의 복합체 형성

• 영문명: Complexation of Bile Acids with beta-Cyclodextrin
• 발행기관: 대한약학회
• 저자명: 이승용(Seung Yong Lee) 정연복(Youn Bok Chung) 한건(Kun Han) 최송암(Song Am Choi)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 78~85쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

From phase solubility studies bile acids and bile salts were found to form stable inclusion complexes with beta-cyclodextrin in aqueous solution. Stability constant of bile acids were larger than that of bile salts. Phase solubility diagrams of most bile acids showed Higuchi''s AL type but lithocholic acid showed Bs type. Not only the solubility of bile acids but also that of beta-cyclodextrin increased, especially in cases of cholic acid and ursodeoxycholic acid. Solubility increase of bile acids from their beta-cyclodextrin inclusion complex followed the order : cholic acid>ursodeoxycholic acid>chenodeoxycholic acid>deoxycholic acid>lithocholic acid. It seems that solubility of inclusion complexes was directly related with the hydrophilicity of bile acids.

키워드

Bile acids bile salts beta-cyclodextrin inclusion complex phase solubility stability constant.