Eicosanoids가 뇌허혈증 흰쥐의 에너지대사 및 Ca++ 이동에 미치는 영향

• 영문명: The Effect of Eicosanoids on Cerebral Energy Metabolism and the Ca++ Concentration in Ischemic Rats
• 발행기관: 대한약학회
• 저자명: 한현정(Hyun J. Han) 이용규(Youg K. Lee) 신정희(Jeung H. Shin) 윤재순(Jae S. Yun)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 57~66쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca++([Ca++]i) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100mg/ml/Kg/day) or DHA(16mg/ml/Kg/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of [Ca++]i under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of [Ca++]i under ischemia by N2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca++ concentration.

키워드

Eicosapentaenoic acid Docosahexaenoic acid Ischemia ATP Glucose Creatine phosphosphate Lactic acid Ca++