파두와 황련의 수용성 혼합물(CP2)부터 분리된 항암성분의 구조확인 및 세포독성에 대한 연구

• 영문명: Identification of Active Component Isolated from Croton tiglium and Coptis japonica Aqueous Mixture(CP2) and Studies of Its Cytotoxic Effect
• 발행기관: 대한약학회
• 저자명: 김정한(Jung Han Kim) 이상준(Sang Jun Lee) 한영복(Young Bok Han) 김종배(Jong Bae Kim)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 31~37쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

Active fraction, P2, was isolated from natural anti-cancer drug, CP2, by HPLC. We confirmed that P2, includes most of the Isoguanosine and minor components, Berberine and other protoberberine alkaloids, by 1H-NMR and 13C-NMR and measured the cytotoxicity of P2, against various tumor cell-lines. P2, was very effective to all tumor cell-lines, especially to human colon cancer SNU-C2A(ED50; 24mcg) and liver cancer HEP-3B(ED50; 27mcg).

키워드

CP2 Isoguanosine berberine protoberberine alkaloids cytotoxic effect.