Brine Shrimp Bioassay를 이용한 해양생물의 세포독성검색

• 영문명: Screening on Cytotoxicity of Marine Organisms Usign Brine Shrimp Bioassay
• 발행기관: 대한약학회
• 저자명: 손병화(Byeng Wha Son) 조용진(Yong Jin Cho) 이대령(Dae Ryoung Yi) 노연숙(Yeon Suk Roh) 이선미(Sun Mi Lee) 최홍대(Hong Dae Choi)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 527~531쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

As a part of chemical study on the bioactive metabolites from marine organisms, we have investigated cytotoxicity using brine shrimp bioassay for each solvent fractions of the marine algae(12 species), marine sponges(3 species), coelenterates(2 species), echinoderms(4 species), marine molluscs(17 species), and ascidians(2 species), respectively. As the results, chloroform extract of Stichopus japonicus (LC50 : 274 mcg/ml), ethyl acetate extract of Anthocidaris crassispina(LC50 : 121mcg/ml), n-butanol extract of Undaria pinnatifida (LC50 : 178mcg/ml), and water extract of Thais clavigera (LC50 : 61mcg/ml) displayed the most significant cytotoxic activity against brine shrimp. Among the marine organisms tested, echinoderms and marine molluscs were thought to be the most active Phylums on screening of new bioactive compounds.

키워드

Marine organisms Cytotoxic activity Antitumor compounds Brine shrimp bioassay.