일차 배양한 흰쥐의 간세포에서 사염화탄소로 인한 독성에 미치는 비테인의 효과

• 영문명: Effects of Betaine on the CCl4-Induced Toxicity in Primary Cultured Rat Hepatocytes
• 발행기관: 대한약학회
• 저자명: 김선여(Sun Yeou Kim) 김홍표(Hong Pyo Kim) 이미경(Mi Kyeong Lee) 김승희(Seung Hee Kim) 문애리(A Ree Moon) 한형미(Hyung Mi Han) 허훈(Hoon Huh) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제37권 제5호 (1993년), 499~503쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

Betaine, a major component of Lycii Fructus, was evaluated for its anti-hepatotoxic activity on carbon tetrachloride-induced hepatotoxicity in primary cultured rat hepatocytes. Betaine was found to attenuate carbon tetrachloride-induced hepatotoxicity both morphologically and biochemically. Typical hepatocyte necrosis due to carbon tetrachloride seemed to be reduced by 50 to 500mcM of betaine under microscopical observation. The value of glutamic pyruvic transaminase released from the hepatocytes into the medium significantly decreased as betaine concentration increased. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride-induced hepatotoxicity. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride.

키워드

Carbon tetrachloride cytochrome P-450 7-ethoxycoumarin-O-deethylase glutathione-Stransferase glutamic pyruvic transaminase hepatotoxicity primary cultured rat hepatocytes.