두릅나무 부탄올 추출물이 지질 관산화에 미치는 영향

• 영문명: Effects of Butanol Extract of Aralia elata on Lipid Peroxidation
• 발행기관: 대한약학회
• 저자명: 서보권(Bo Gwon Seo) 정연봉(Yeoun Bong Chung) 김용규(Yong Kyu Kim) 신옥진(Ok Jin Shin) 이종철(Chong Chul Lee)
• 간행물 정보: 『약학회지』제37권 제3호 (1993년), 270~277쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

It is well known that lipidperoxide, formed in vivo, induced the denaturation of enzyme and destruction of cell membrane to acute injury of tissue. Aralia elata have physiological activates, the improvement of lipid metabolism, antidiabetic activity etc., which was thought to have the relationship to lipid peroxidation. The anti-lipidperoxidative effect of Aralia elata have not yet established. In this study, we examined the anti-lipidperoxidative effects of Aralia elata (Butanol fraction) on CCl4 induced lipidperoxidation in rats, and elucidated the anti-lipidperoxidative mechanism. In rat liver homogenate intoxicated with CC14 (0.5ml/100g), BuOH fraction of Aralia elata (80mg/Kg/day) exhibited 85.41% anti-lipidperoxidative effect but in serum 69.63% inhibitory effects, respectively. In mitochondrial and microsomal fraction showed inhibition of 55.85% and 69.30%, respectively. In order to elucidate the mechanism of anti-lipidperoxidation effects of Aralia elata, enzymatic (NADPH dependent) and non-enzymatic (Ascorbic acid catalyzed) reaction, in vitro, were performed. In enzymatic reation, Aralia elata exhibited 59.43% anti-lipidperoxidation effects, but in non-enzymatic reaction exhibited 43.27% inhibition. Therefore, it is noteworthy that antioxidative power of them may mainly results from the inhibition by enzymatic reaction.

키워드

Aralia elata lipid-peroxidation antidiabetic activity .