해양동물 눈알고둥 렉틴의 림프구 분열 효과 및 면역화학적 특성

• 영문명: Lymphocytes Mitogenic and Immunochemical Properties of the Lectins from Marine Animal Lunella coronata coreensis
• 발행기관: 대한약학회
• 저자명: 소명숙(Myung Suk So) 전경희(Kyung Hee Jeune) 정시련(See Ryun Chung)
• 간행물 정보: 『약학회지』제37권 제3호 (1993년), 254~261쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

Developing new substance for immunosuppressor or immunomodulator from natural products is extremely important in the present biomedicine. In this paper, we focused our efforts on the mitogenicity and immunochemical properties of the two lectins (LCC-I, LCC-II) obtained from marine animal Lunella coronata coreensis. Immunochemical techniques were employed to elucidate the structural and/or functional similarities between the LCC lectins. Molecular weight of the LCC lectins, LCC-I and LCC-II were estimated to be around 60 KD and 66-70 KD, respectively. LCC lectins were mitogens for murine splenic lymphocytes, and the optimum mitogenic doses were 31.25mcg/ml and 3.91mcg/ml, respectively. LCC-II lectin was a good mitogen toward human peripheral lymphocytes at a concentration about 31.25mcg/ml.

키워드

Lectins Lunella coronata coreensis immunodiffusion immunoelectrophoresis molecular size mitogenic activity.