항진균제 Naftifine 구조와 관련된 알릴아민류의 합성

• 영문명: Synthesis of Naftifine-Related Allylamine as a Potential Antimycotics
• 발행기관: 대한약학회
• 저자명: 김욱(Wook Kim) 박은주(Eun Ju Park) 서희경(Hee Kyong Seo) 신부안(Boo Ahn Shin) 최보길(Bo Gil Choi) 정병호(Byung Ho Chung)
• 간행물 정보: 『약학회지』제37권 제3호 (1993년), 247~253쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2''e-2''h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH4 yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH4 or hcooh to give 4a-4h.