베타 락탐계 항생제의 합성 및 항균력

• 영문명: Synthesis of beta-Lactam Antibiotics and Their Antibacterial Activity
• 발행기관: 대한약학회
• 저자명: 홍석기(Seog Ki Hong) 남재우(Jae Woo Nam) 이경태(Kyung Tae Lee) 신관석(Kwan Seog Sin)
• 간행물 정보: 『약학회지』제37권 제2호 (1993년), 158~162쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.04.30

영문 초록

6beta-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid(7a~7c) and 7beta-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidocephalosporanic acid(8a~8c) were synthesized and tested in vitro antibacterial activity. Of these new penicillins exhibited good antibacterial activity against Gram-positive bacteria whereas none of the compounds possessed the activity against Gram-negative bacteria at the concentration tested.