산조인 및 대추, 대추나무로부터 단리한 아포르핀과 환상 펩티드 알칼로이드의 생쥐에 대한 진정작용

• 영문명: Sedative Activity of Aporphine and Cyclopeptide Alkaoids Isolated from the Seed of Zizyphus Vulgaris var. Spinosus, and the Fruits and Stem Bark of Zizyphus Jujuba var. Inermis in mice
• 발행기관: 대한약학회
• 저자명: 한병훈(Byung Hoon Han) 박명환(Myung Hwan Park) 한용남(Yong Nam Han)
• 간행물 정보: 『약학회지』제37권 제2호 (1993년), 143~148쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.04.30

영문 초록

The objective of this study was to evaluate the sedative activity of four aporphine alkaloids (APA) and nine cyclopeptide alkaloids(CPA), which had been isolated from the seeds (sanjoin) of Zizyphus vulgaris var. spinosus, and the fruits and stem bark of Zizyphus jujuba var. inermis. The assessment of sedative activity was carried out, employing a hexobarbital-induced sleeping time method in mice. When the relative sedative potency of sanjoinine-A(CPA) was given as one unit, those of nuciferine (APA), lysicamine (APA), chlorpromazine (positive control), and sanjoinine -Ahl (an epimer of sanjoinine-A) were 13, 6.5, 5, and 3, respectively. The sedatvie activities of other CPAs were much lower than those of sanjoinine-A and -Ahl, and other APAs were not active. On heat treatment, nuciferine and lysicamine were degraded into some artifacts which exhibited no sedative activity, while sanjoinine-A was converted into sanjoinine-Ahl which showed more potent sedative activity. These results suggested that nuciferine and sanjoinine-A were major sedative components of native sanjoin, and that sanjoinine-A and its epimeric artifact, sanjoinine Ahl were the active principles of roasted sanjoin. It provides a scientific basis for heat-processing (roasting) of this Oriental medicine.

키워드

Zizyphus vulgaris Zizyphus jujuba sedative cyclopeptide alkaloid aporphine alkaloid.