타아조로[3,2-a][1,3]디아제핀-베타인의 고리변환 반응

• 영문명: Ring Transformation Reaction of Thiazolo[3,2-a][1,3]diazepinium-Betaine
• 발행기관: 대한약학회
• 저자명: 박미선(Mi Seon Park) 서명은(Myung Eun Suh) 유경호(Kyung Ho Yoo) 박상우(Sang Woo Park)
• 간행물 정보: 『약학회지』제37권 제2호 (1993년), 113~118쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.04.30

영문 초록

3-Phenyl-5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepine, which has pharmaceutical activities, was reacted with phenyl isothiocyanate to give 3-phenyl-9-phenyl(thiocarbamoyl)-5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepinium-betaine. New biheterocyclic compounds were prepared by the ring transformation reaction of the above reactive betaine with alpha-haloesters and alpha-haloketones such as ethyl bromoacetate, methyl bromoacetate, chloroacetone, and 4''-methoxyphenacyl bromide, respectively. In each ring transformation reaction, two major products supposed to be geometrical isomers were obtained.