N-(2치환스티릴) 카르복사미드류의 합성

• 영문명: Synthesis of N-(disubstituted styryl) Carboxamides
• 발행기관: 대한약학회
• 저자명: 김순옥(Soon Ok Kim) 홍사미(Sa Mi Hong) 이선화(Seon Hwa Lee)
• 간행물 정보: 『약학회지』제36권 제5호 (1992년), 433~439쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.10.29

영문 초록

For the synthesis of tuberin derivatives, N-(disubstituted styryl) carboxamides, the series of cinnamic acids were transformed through chlorides, azides to isocyanates. And then isocyanates were reduced separately by Dibal and Grignard reagent. As a result of antimicrobial susceptibility test, N-(3,4-dichlorostyryl) formamide and N-(3,4-dichlorostyrl) acetamide showed comparatively large activity against some bacteria that is, MIC was respectively 50 ppm, 6.25~50 ppm. MIC of other derivatives was similiar to that of tuberin, about 100.