가토에서 혈압에 관여하는 약물의 작용에 대한 니페디핀의 영향

• 영문명: Effect of Nifedipine on the Action of Drug Participating in Blood Pressure in Rabbits
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 정창주(Chang Ju Jung) 김해석(Hai Suk Kim)
• 간행물 정보: 『약학회지』제36권 제4호 (1992년), 379~389쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.08.30

영문 초록

In order to investigate the effect of nifedipine, Ca2+ channel antagoninst, on the action of some drugs participating in blood pressure, this experiment was performed in rabbits. Nifedipine decreased the pressor actions of norepinephrine, angiotensin and carotid artery clamping, but did not affect the pressor actions of tyramine and depressor actions of acetylcholine and pilocarpine. Nifedipine inhibited the potentiated pressor action of norepinephrine and angiotensin, but did not influence the potentiated pressor action of tyramine in rabbits pretreated with chlorisondamine, ganglionic blocking agent. Nifedipine weakened the potentiated pressor action of norepinephrine, did not affect the pressor action of angiotensin and the potentiated pressor action of tyramine in rabbits pretreated with debrisoquine, sympathetic neuronal blocking agent.