인삼 석유에테르 추출물이 흰쥐에서 여러 발암성물질에 의해 유도된 소핵생성의 억제효과

• 영문명: Anticlastogenic Effect of Petroleum Ether Extract of Panax ginseng Against Carcinogens-induced Micronuclei in Mice
• 발행기관: 대한약학회
• 저자명: 최성규(Sung Gyu Choi) 허문영(Moon Young Heo)
• 간행물 정보: 『약학회지』제36권 제4호 (1992년), 334~340쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.08.30

영문 초록

Ethanol, total saponin and petroleum ether extract of Panax ginseng C.A. Meyer were tested for their anticlastogenic effects against induction of micronuclei by cyclophosphamide and benzo(a)pyrene in mice. Ginseng petroleum ether extract (GPEE) showed the highest suppressive effect among three extracts. GPEE was also tested to compare their anticlastogenic effect against several well-known carcinogens: such as mitomycin C, 7, 12-dimethyl benzo(a)anthracene, ethyl methane sulfonate, dimethylnitrosamine and busulfan. GPEE showed the anticlastogenic effect against most of carcinogens, although there were no significant effects against 7,12-dimethyl benzo(a) anthracene, dimethyl nitrosoamine and busulfan-induced micronuclei.