생쥐에 있어서 에탄올의 면역독성에 미치는 메치오닌 식이의 영향

• 영문명: Effects of Methionine Diets on the Immunotoxicity of Ethanol in ICR Mice
• 발행기관: 대한약학회
• 저자명: 안영근(Young Keun Ahn) 김정훈(Joung Hon Kim) 구기범(Gi Bum Koo) 문재규(Jae Gyu Moon)
• 간행물 정보: 『약학회지』제36권 제4호 (1992년), 303~314쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.08.30

영문 초록

Experiments were performed on mice to investigate the effect of methionine diets (MET) on the immunotoxicity of ethanol. ICR female mice were divided into 5 groups, Met (Basal (B) + O.19% methionine(M), B + 1.71% M and B + 5.13%(M) and ethanol(4%) were administered ad libitum for 21 days. The mice were evaluated for changes in immune status as measured by antibody titer, Arthus reaction, delayed type hypersensitivity (DTH), rosette forming cell(RFC) and plaque forming cell (PFC) to sheep red blood cells (S-RBC). To investigate the change of the non-specific immune response, the number of leukocytes in peripheral blood and phagocyte activity were measured. The results were summarized as follows: (1) The weight ratios of spleen and thymus to body weight were significantly increased by the B + 0.19% M, B + 0.57% M and B + 1.71% M groups in comparison with control group(B), but B + 5.13% M group was significantly decreased. (2) Humoral immune responses were significantly increased by the B + 0.19% M and B + 0.57% M groups in comparison with control group, but B + 5.13% M group was significantly decreased. (3) Cellular immune responses were significantly decreased by the B + 1.71% M and B + 5.13% M groups in comparison with control group. (4) Phagocyte activities were significantly increased by the B + 0.19% M, B + 0.57% M and B + 1.71% M groups in comparison with control groups, but B + 5.13% M group was significantly decreased. (5) The number of circulating leukocyte was significantly increased in the B + 0.19% M and B + 0.57% M groups in comparison with control group, but B + 5.13% M group was significantly decreased.