새로운 세파로스포린계의 항생제 합성과 항균성

• 영문명: Synthesis and Antimicrobial Activity of Cephalosporin Antibiotic Derivatives
• 발행기관: 대한약학회
• 저자명: 고옥현(Ok Hyung Ko) 강형룡(Hyung Ryong Kang) 유진철(Jin Cheol Yoo) 김경수(Gyung Soo Kim) 홍석순(Suk Soon Hong) 김영수(Young Soo Kim) 황화영(Hwa Young Hwang)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 150~158쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

7beta-(5-Aryl-2H-tetrazol-2-yl)acetamidocephalosporanic acid (23~26) and 7beta-(5-Aryl-4-phenyl-4H-1,2,4-triazol-3-yl)thioacetamidocephalosporanic acid were synthesized by condensation of 5-Aryl-2H-tetrazol-2-acetyl choloride(17~20) and 5-Aryl-4-phenyl-4H-1,2,4-triazol-3-thioacetyl chloride(22~24) with 7-Aminocephalosporanic acid (7-ACA), respectively. These seven compounds were tested in vitro antimicrobial activity. These exhibited good antimicrobial activity against Gram-positive bacteria whereas most compounds showed decreased antimicrobial activity against Gram-negative bacteria.