수종 생약의 항알레르기 작용

• 영문명: Anti-allergic Action of Some Medicinal Plants
• 발행기관: 대한약학회
• 저자명: 최수형(Soo Hyung Choi) 김영란(Young Ran Kim) 임동구(Dong gu Lim) 배은옥(Eun Ok Bai)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 140~149쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

Anti-allergic action of each water extracts of some crude drugs was investigated in mice and rats. The activity of hyaluronidase which was used in the screening test of anti-allergic action was inhibited significantly by Amomi Semen, Asiasari Radix, Cimicifugae Rhizoma, Cinnamomi Ramulus, Glycyrrhizae Radix and Scutellariae Radix. The 48-hour homologous passive cutaneous anaphylaxis(48-hr PCA) in mouse ear was inhibited significantly by intraperitoneal(i.p.)injection of Amomi Semen, Cimicifugae Rhizoma, and ketotifen, a comparative drug of an anti-allergic action. The increase of vascular permeability induced by histamine or serotonin was inhibited significantly by i.p. injection of Ammi Semen, Cimicifugae Rhizoma, Cinnamomi Ramulus and ketotifen. In rat dorsal skin, the increase of vascular permeability which was induced by histamine, serotonin or compound 48/80 was inhibited significantly by i.p. inhibit 48-hr PCA and the increase of histamine, serotonin or compound 48/80-induced vascular permeability in mice and the increase of histamine, serotonin or compound 48/80-induced vascular permeability in mice and rats. Theses results suggest that each water extract of Amomi Semen and Cimicifugae Rhizoma has anti-allergic action.