1,4-나프로퀴논 유도체의 항균 및 항진균 작용

• 영문명: Antibacterial and Antifungal Activities of 1,4-Naphthoquinone Derivatives
• 발행기관: 대한약학회
• 저자명: 유충규(Chung Kyu Ryu) 류재천(Jae Chun Ryu) 정세영(Sae Young Chung) 김동현(Dong Hyun Kim)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 110~114쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

In order to evaluate the antimicrobial effect of 2,3-substituted-1,4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1,4-naphthoquinones and subjected to antibacterial and antifungal activities, in vitro, against Escherichia coli HIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 andTricophyton mentagrophytes 6085. Among these derivatives 3,9,18 and 23 showed the potent antibacterial activities. 18,23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.