월견초종자유가 생쥐의 면역반응에 미치는 영향

• 영문명: Effects of Eventing Primrose Oil on the Immune Responses in Mice
• 발행기관: 대한약학회
• 저자명: 안영근(Young Keun Ahn) 오연준(Yun Joon Oh) 김정훈(Joung Hoon Kim)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 93~109쪽, 전체 17쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

The purpose of this experiment was to investigate both the immunomodulatory effect of evening primrose(EP) oil and the effects of EP oil on immunoregulation by cyclophosphamide in mice. EP oil at doses of 0.1, 0.2 and 0.4ml/kg were orally administered to ICR male mice once daily for 28 consecutive days. Cyclophosphamide was injected intraperitoneally to ICR mice with a single dose of 5mg/kg at 2 days before secondary immunization . Mice were sensitized and cellular immune responses and non-specific immune response. The results of this study were summarized as follows; (1) The humoral immune responses such as hemagglutination titer(HA), hemolysin titer(HY)Arthus reaction and plaque forrming celll(PFC) were significantly enhanced in the low dose EP oil administered groups(0.1 and 0.2ml/kg). However, in the high dose EP oil administered group(0.4ml/kg) the responses were significantly lowered. (2) In the case of cellular immune responses, delayed type hypersensitivity reaction(DTH) was significantly decreased in EP oil whereas rosette forming cell(RFC)was remarkably enhanced. (3) Activities of natural killer cells and phagocyte were generally enhanced in EP oil. In addition, serum albumin and globulin were also increased.