선천성 고혈압 쥐에서 고혈압 지속현상과 중추신경계 노르아드레날린성 신경활성과의 상관성

• 영문명: Relationship between Maintenance of Hypertension and Central Noradrenergic Nervous System Activity in Spontaneously Hypertensive Rats
• 발행기관: 대한약학회
• 저자명: 고광호(Kwang Ho Ko) 신재수(Jae Soo Shin) 김미영(Mie Young Kim)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 334~342쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

The relationship between the maintenance of hypertension and the central noradrenergic nervous system activity in spontaneously hypertensive rats (SHR) was studied. The norepinephrine turnover rates in 5 brain areas; telencephalon, hypothalamus/thalamus, midbrain, pons/medulla, cerebellum as a measure of noradrenergic neuronal activity were measured at the ages of 14 weeks in SHR and normotensive Wistar rats. In 14-week old SHR, blood pressure was significantly higher than in normotensive rat, and central norepinephrine turnover rates were significantly greater in telencephalon, hypothalamus/thalamus, midbrain. There were no differences between norepinephrine turnover rates in pons/medulla, cerebellum of SHR and those of normotensive rats.