항암성 물질 Psorospermin의 합성중간체인 6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol의 합성

• 영문명: Synthesis of 6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol for the Preparation of Psorospermin
• 발행기관: 대한약학회
• 저자명: 고옥현(Ok Hyun Ko)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 329~333쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol was synthesized by means of the eight steps, such as allylether, Claissen rearrangement, tosylation, oxidation, Wittig reaction, reduction and epoxidation from 3,5-dimethoxyphenol. The epoxidation of 6-[3-(hydroxymethyl)-2-butenyl]-3,5-dimethoxy phenol using the L-(+)-diethyltartrate(DET), titanium(IV) isopropoxide Ti[(O-iPr)4] and t-butylhydroperoxide(TBHP) is described.