Bacillus licheniformis EMR 균주에서 린코사마이드계 항생물질에 의한 유도내성

• 영문명: Inducible Resistance to Lincosamide Antibiotics by Lincosamide Antibiotics in Bacillus licheniformis
• 발행기관: 대한약학회
• 저자명: 최응칠(Eung Chil Choi) 우정원(Jung Won Woo) B. 와이스브럼(Bernard Weisblum)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 317~322쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

To clarify resistance mechanisms of lincosamide antibiotics, it was examined whether lincosamide antibiotics was able to induce high resistance to macrolide and lincosamide antibiotics against EMR-1 strain of Bacillus species. And it was also examined whether the inducible resistance was plasmid-mediated or chromosome-mediated. This strain was identified as Bacillus licheniformis by its morphological and physiological characteristics. The subinhibitory concentrations of lincomycin and clindamycin induced high resistance in the strain to lincosamide antibiotics, but not to macrolide antibiotics. The inducible resistance was not eliminated by treating the strain with ethidium bromide, and plasmid was not identified by the alkaline lysis method of plasmid preparation. These results indicate, therefore, that the inducible resistance to macrolide and lincosamide antibiotics in the strain may be chromosome-mediated, not plasmid-mediated.