Epsilon-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine의 합성

• 영문명: Preparation of epsilon-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine
• 발행기관: 대한약학회
• 저자명: 김정균(Jack C. Kim) 조인섭(In Seop Cho)
• 간행물 정보: 『약학회지』제27권 제2호 (1983년), 177~179쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.06.30

영문 초록

A copper complex of epsilon-N-[(2-chloroethyl)carbamoyl]-L-lysine was prepared by the treatment of the L-lysine copper complex with 2-chloroethyl isocyanate in cold water. Within the L-lysine copper complex molecule, the alpha-amino and carboxyl groups are bounded to Cu2+, but the epsilon-amino group is free and can react with carbamoylating agents. A potential antitumor agent, epsilon-N-[(2-chloroethyl) nitrosocarbamoyl]-L-lysine was synthesized by nitrosation of this copper complex with Na N02 in anhydrous formic acid, followed by the passage of H2S gas.