Nalidixic Acid와 Probenecid의 약물 상호 작용

• 영문명: Drug Interaction of Nalidixic Acid and Probenecid in Rabbits
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi)
• 간행물 정보: 『약학회지』제27권 제2호 (1983년), 133~138쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.06.30

영문 초록

The interaction between nalidixic acid and probenecid was studied pharmacokinetically in rabbits. The blood level and the area under the concentration curve(AUC) of nalidixic acid administered orally in dose of 100mg/kg was elevated by the coadministration of probenecid. Probenecid inhibited both the urinary excretion and the biliary excretion of nalidixic acid. Therefore, biological half-life of nalidixic acid was prolonged by the coadministrarion of probenecid. It was considered that the coadministration of probenecid is more desirable than the single administration of nalidixic acid for the therapeutic effect.