이성분계 공침물에 관한 연구

• 영문명: Studies on the Coprecipitates of Two Ingredients with PVP
• 발행기관: 대한약학회
• 저자명: 백우현(Woo Hyun Paik) 김정우(Joung Woo Kim) 송영준(Young Joon Song)
• 간행물 정보: 『약학회지』제25권 제4호 (1981년), 187~192쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.12.30

영문 초록

In order to increase the dissolution rate on the mixture of sulfamethoxazole and trimethoprim (SMX-TMP), their coprecipitates with polyvinylpyrrolidone (PVP) were studied. Coprecipitates prepared with various ratios of SMX and TMP were examined such as hygroscopicity, apparent solubility, apparent partition coefficient and the dissolution behavior of SMX-TMP''s coprecipitates and their physical mixtures. The hygroscopicity of coprecipitates were less than that of physical mixtures. The apparent solubility and dissolution rate of SMX-TMP''s coprecipitates were found to be greatly increased. The dissolution rates of SMX and TMP in the coprecipitates were decreased when the ratio of two ingredients to PVP was smaller, and the dissolution rate of SMX was increased when the ratio of SMX to TMP was larger.