Riboflavin과 Barbiturate와의 분자간 상호작용

• 영문명: Molecular Interaction of Riboflavin and Barbiturates
• 발행기관: 대한약학회
• 저자명: 유병설(Byung Sul Yu) 이상득(Sang Deuk Lee) 이상종(Sang Jong Lee) 정현호(Hyun Ho Chung)
• 간행물 정보: 『약학회지』제25권 제4호 (1981년), 167~173쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.12.30

영문 초록

Spectroscopic investigation has been carried out to know the binding mechanism of riboflavin with barbiturates, such as pbenobarbital and amobarbital in chloroform solution by using infrared and nuclear magnetic resonance spectra. Phenobarbital and isoalloxazine form a 1:1 cyclic hydrogen bonded dimer through the 3-N imino and the 2-C carbonyl groups of the isoalloxazine ring of the latter, and the 1-N(or 3-N) imino and the 2-C carbonyl groups of the pyrimidine ring of the former. Amobarbital and riboflavin form a 1:1 cyclic hydrogen bonded dimer by the same mode of phenobarbital.