인삼사포닌이 Adrenaline에 의한 고혈당 및 고지방혈증에 미치는 영향

• 영문명: Effect of Ginseng Saponin on Adrenaline-Induced Hyperglycemia and Hyperlipidemia
• 발행기관: 대한약학회
• 저자명: 이동권(Dong Kwon Rhee) 임창진(Chang Jin Lim) 박은희(Eun Hee Park) 홍순근(Soon Keun Hong)
• 간행물 정보: 『약학회지』제25권 제2호 (1981년), 49~55쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.06.30

영문 초록

To elucidate the effect of ginseng saponin on adrenaline-induced hyperglycemia and hyperlipidemia, ginseng saponin was administered before and after administration of adrenaline, and concentration of glucose, triglyceride(TG), and free fatty acid (FFA) as well as lipase activity in plasma was determined. 1) Glucose concentration was slightly increased by administration of ginseng saponin at 1 hour before and 10 minutes after adrenaline administration, but decreased by administration of ginseng saponin at 7 and 4 hours before adrenaline administration. TG and FFA concentration was also greatly inhibited by administration of ginseng saponin in advance. 2) When ginseng saponin 3, 10, 30mg/kg were administered 7 hours before adrenaline administration, glucose and TG concentration as well as lipase activity were inhibited in proportion to the dose of ginseng saponin, but FFA concentration was slightly inhibited. 3) It was suggested that protopanaxatriol group have potentiating effect on adrenaline induced hyperglycemia but protopanaxadiol group have inhibitory effect. And ginseng saponin seems to have strong inhibitory action on TG mobilization into blood and stimulatory effect on esterification of FFA in liver and adipose tissue.