비대칭적인 피리다진 유도체의 싸이올레이션; 새로운 메틸피리다진의 위치이성질체 합성

• 영문명: Thiolation of Asymmetry Pyridazines; Synthesis of a Regioisomer of New Methylpyridazines
• 발행기관: 대한약학회
• 저자명: 박해선 박명숙
• 간행물 정보: 『약학회지』제58권 제6호 (2014년), 371~377쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.31

영문 초록

A new series of 3-alkylthio-6-allylthio-4(or 5)-methylpyridazines (6a-e)-(7a-e) was synthesized from citraconic anhydride (1) for development of candidates possessing anticancer activity. The process involves the formation of pyridazine ring, dichlorination, monoallythiolation, and further another alkylthiolation. Compounds 6a-e, and 7a-e were prepared from 6-allylthio-3-chloro-4-methylpyridazine (4) or 6-allylthio-3-chloro-5-methylpyridazine (5) via nucleophilic substitution reac-tion with alkylthiol anion as nucleophile. Intermediates 4, and 5 could be converted to target pyridazines 6a-e, and 7a-e using 1~1.5 equivalent of alkylthiol at reflux temperature in methanol in the presence of sodium hydroxide. The structures of the synthetic compounds were characterized using NMR, IR, and GC-MS analyses.

목차

실험방법

실험결과 및 고찰

결 론

감사의 말씀

References

키워드

diallyl disulfide asymmetry pyridazine methylpyridazines alkylthiolation regioisomer