화살나무(Euonymus alatus)와 회잎나무(Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama) 추출물의 대식세포에 대한 항염증 활성비교

• 영문명: Compared Anti-inflammatory Activity of Euonymus alatus and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama Extract on Macrophages
• 발행기관: 대한약학회
• 저자명: 김정화 오수연 한주환 이귀용 안찬기 황방연 이재권
• 간행물 정보: 『약학회지』제58권 제6호 (2014년), 357~363쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.31

영문 초록

Euonymus alatus (EAE) and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama (EACHE) belong to the Celastraceae family and are one of the medicinal herbs used in traditional medicine as a therapeutic agent for blood cir-culation diseases. In this study, we prepared leaves methanolic extract of EAE (L-EAE), twigs methanolic extract of EAE (T-EAE), leaves methanolic extract of EACHE (L-EACHE) and twigs methanolic extract of EACHE (T-EACHE), and com-pared their anti-inflammatory activities. To analyze the anti-inflammatory activities, Raw 264.7 cells were used, since they are immature-macrophages and easily matured by lipopolysaccharide (LPS) stimulation. All extracts showed anti-inflam-matory activities in the activated Raw 264.7 cells. That is, we showed that L-EACHE and T-EACHE are potent inhibitors of the production of nitric oxide and pro-inflammatory cytokines. These results are expected to serve as a guide for future studies on the ability of Celastraceae family to inhibit acute and chronic inflammatory diseases.

목차

재료 및 실험방법

실험결과

고 찰

결 론

감사의 말씀

References

키워드

Euonymus alatus Euonymus alatus for ciliatodentatus (Franch. & Sav.) Hiyama macrophage anti-inflam- mation