구척의 항산화 활성 및 지표성분 동정

• 영문명: Anti-oxidant Activities and Identification of Standard Compounds from Cibotii Rhizoma
• 발행기관: 대한약학회
• 저자명: 김소화 김은영 황완균
• 간행물 정보: 『약학회지』제58권 제5호 (2014년), 314~321쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.31

영문 초록

Cibotii Rhizoma, the dried rhizome of Cibotium barometz J. Smith (C. barometz), has long been used to treat bone or nervous system disorders. In this regard, we isolated three main phenolic compounds, onitin-4-O-β-D-glu- copyranoside (1), irisdichototins E & F epimeric mixture (2), and protocatechuic acid (3) from C. barometz methanol extract. In addition, we screened their antioxidative activities by DPPH, ABTS radical, and superoxide scavenging assays. Among these three compounds, irisdichototins E & F and protocatechuic acid showed strong antioxidant activities. Also, the anti-oxidant activities of the C. barometz extracts were proportional to the contents of irisdichototins E & F and protocatechuic acid, thus these two phenolic compounds could be main active compounds of C. barometz. In addition, onitin-4-O-β-D-glu-copyranoside is considered as a marker compound of C. barometz because this compound is specifically contained in C. barometz which belongs to Pteridophyta order. A rapid analysis method for the simultaneous determination of phenolic com-pounds was also developed by UPLC (Ultra Performance Liquid Chromatography). Using the developed method, the two active compounds (irisdichototins E & F and protocatechuic acid) and a marker compound (onitin-4-O-β-D-glucopyranoside) were successfully quantified in 14 commercial samples that were collected from different regions.

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감사의 말씀

References

키워드

Cibotii Rhizoma onitin-4-O-β-D-glucopyranoside irisdichototins E & F epimeric mixture protocatechuic acid antioxidative activity UPLC