합성마약류의 의존성 평가를 위한 구조활성상관(QSAR) 모델 적용

• 영문명: Quantitative-Structure Activity Relationship (QSAR) Model for Abuse-liability Evaluation of Designer Drugs
• 발행기관: 대한약학회
• 저자명: 윤재석
• 간행물 정보: 『약학회지』제58권 제1호 (2014년), 53~57쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.02.28

영문 초록

n recent, the abuse of newly-emerging psychoactive drugs, ('designer drugs') is a rapidly increasing problem in Korean society. Quantitative-structure activity relationship (QSAR) is an alternative method to predict bioactivities of new abused compounds. In this study, cathinone-related new designer drugs, 4-methylbuphedrone and 4-methoxy-N,N-dim-ethylcathinone were tested for prediction of the bioactivity with QSAR model. The bioactivity of 4-methylbuphedrone and 4-methoxy-N,N-dimethylcathinone was similar to those of methylone. These results suggest that the prediction with QSAR model may provide scientific evidences for regulatory decision.

목차

designer drug;QSAR;bioactivity;regulation;addiction

키워드

designer drug QSAR bioactivity regulation addiction