호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성

• 영문명: Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
• 발행기관: 대한약학회
• 저자명: 주시몽 홍윤정 양기숙
• 간행물 정보: 『약학회지』제58권 제1호 (2014년), 12~15쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.02.28

영문 초록

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gon- orrhea, favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and anti-inflammatory activity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO pro-duction in RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-D-glucopyranoside (2). Compounds 1 and 2 showed potent activities compared with L-NMMA (N G -monomethyl-L-arginine).These results suggested that the stilbene compounds isolated from Polygonum uspidatum might be used as antiin-flammatory agents.

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실험방법

실험결과 및 고찰

결 론

참고문헌

키워드

Polygonum cuspidatum resveratrol trans-resveratrol 3-O-β-D-glucopyranoside antiinflammatory agents