새로운 옥사졸리디논계 항균제 LCB01-0371에 대한 Enterococcus faecalis의 내성 기전

• 영문명: Resistance Mechanism of Enterococcus faecalis to LCB01-0371, a New Oxazolidinone
• 발행기관: 대한약학회
• 저자명: 이현희 이수노 곽진환
• 간행물 정보: 『약학회지』제58권 제1호 (2014년), 7~11쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.02.28

영문 초록

To study the resistance mechanism of E. faecalis to LCB01-0371, several resistant mutants to LCB01-0371 or linezolid were isolated by step-wise selection. The frequency of spontaneous mutations resistant to LCB01-0371 was lower than that of linezolid in E. faecalis. The genetic variations in resistant mutants were analyzed by DNA sequencing of domain V of 23S rRNA in each mutant. The first-step mutant to LCB01-0371 had a G2576T point mutation in V domain of 23S rRNA. However, no resistant mutant to LCB01-0371 was isolated in second-step mutant selection.

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키워드

LCB01-0371 resistance mechanism Oxazolidinone E faecalis