알츠하이머 치매 환자에서의 인지영역별 기능과 병식과의 연관성

• 영문명: Association between Cognitive Subdomains and Insight in Alzheimer Disease : A Clinical Research Center for Dementia of South Korea Study
• 발행기관: 대한노인정신의학회
• 저자명: 김영돈(Youngdon Kim) 김상하(Sang Ha Kim) 명우재(Woojae Myung) 최준배(Junbae Choi) 윤혜연(Hyeyeon Yoon) 강효신(Hyo Shin Kang) 나덕렬(Duk L. Na) 김성윤(Seong Yoon Kim) 이재홍(Jae-Hong Lee) 한설희(Seol-Heui Han) 최성혜(Seong Hye Choi) 김상윤(Sang Yun Kim) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제18권 제2호, 76~80쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2014.10.31

영문 초록

Objective：The aim of this study was to investigate the association between cognitive subdomains and insight into one’s cognitive impairment in patients with Alzheimer disease (AD). Methods：We recruited 1,722 patients with AD from the Clinical Research of Dementia of South Korea study and designed a cross-sectional study. Each patient’s cognitive subdomain was assessed by using the Seoul Neuropsychological Screening Battery-Dementia version. Severity of dementia was evaluated by Korean version of Mini-Mental Status Examination (K-MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB). Insight into one’s cognitive impairment was categorized as ‘with insight’ and ‘without insight’ through interview with patient’s caregivers. Results：Among the 1,722 patients with AD, 1,475 patients were included in the ‘with insight’ group and the remaining 247 patients were included in the ‘without insight’ group. Subjects in the ‘without insight’ group had lower K-MMSE and CDR-SB scores than those in the ‘with insight’ group. After controlling for demographic data and dementia severity, higher scores on both attention function (odds ratio=1.12, 95% confidence interval : 1.03-1.21) and frontal-executive function (odds ratio=1.03, 95% confidence interval : 1.01-1.05) significantly predicted the membership to ‘with insight’ group. Conclusion：In patients with AD, attention and frontal-executive function were associated with insight into one’s cognitive impairment.

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키워드

알츠하이머 치매 치매 인지능력 병식 Alzheimer disease Dementia Cognitive function Insight