Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia

• 발행기관: 대한해부학회
• 저자명: Jae-Chul Lee Joon Ha Park Ok Kyu Park In Hye Kim Bing Chun Yan Ji Hyeon Ahn Seung-Hae Kwon Jung Hoon Choi Jong-Dai Kim Moo-Ho Won
• 간행물 정보: 『Anatomy and Cell Biology』Vol.46(3), 183~190쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.09.30

영문 초록

Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications.

목차

Abstract

Introduction

Materials and Methods

Results

Discussion

References

키워드

Hypoxia-ischemia Neuronal death Neuroprotection Radix Salvia miltiorrhiza