녹차의 포름알데히드에 의한 인간 망막 색소 상피세포 사멸 차단 효과

• 영문명: Green Tea Catechins Protect Formaldehyde-induced Cell Death in Human Retinal Pigment Epithelial Cells
• 발행기관: 한국차학회
• 저자명: 박수현(Soo-Hyun Park)
• 간행물 정보: 『한국차학회지』제18권 제4호, 92~96쪽, 전체 5쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

Green tea (GT) is consumed throughout the world because of its beneficial effects on preventing the onset of many diseases in humans. The major components of GT are epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG) and epicatechin (EC). Formaldehyde (FA) is a volatile substance that is found in many environmental conditions, such as pesticides and new buildings. The eye is a very sensitive organ to a range of insults. Retinal pigment epithelial cells are one of the components of the eye, whose dysfunction is implicated in diseases, such as diabetic retinopathy and macular degeneration. This study examined the preventive effect of green tea extracts on FA-induced dysfunction of ARPE cells, a human retinal epithelial cell line. FA induced a decrease in cell viability, stimulated lactate dehydrogenase (LDH) activity and increased lipid peroxide (LPO) formation. A treatment with the GT extracts (GTE, 10 mg/ml) prevented FA-induced cell death and LDH activity in ARPE cells. In addition, the treatment of EGCG, EGC, ECG, and EC also prevented the FA-induced decrease in cell viability, increased LPO formation and decreased the GSH contents. Overall, GT prevented FA-induced cell death mainly by decreasing oxidative stress in ARPE cells. In conclusion, GTE prevents the FA-induced decrease in cell viability by decreasing the level of oxidative stress in ARPE cells.

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키워드

green tea retinal pigment epithelial cells oxidative stress