흰쥐의 탈신경근 위축에 미치는 운동의 효과

• 영문명: Exercise Effects on the Atrophy of Denervated Muscles in Rat
• 발행기관: 한국전문물리치료학회
• 저자명: 윤범철(Yoon Bum-chul) 유병규(Yu Byong-kyu) 이명화(Lee Myong-hwa)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제7권 제3호, 34~48쪽, 전체 15쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2000.09.30

영문 초록

The purpose of this study was to determine the effects of mild-intensity exercise training on the denervated muscle atrophy in the sciatic nerve injured rat. Thirty-six male Sprague-Dawley rats (250∼300 g) were randomly assigned into three groups; sham-denervated group (n=8), denervated group (n=8), and denervated-exercised group (n=20). Exercise consisted of treadmill running at 20 m/min speed with 0% grade of 30 min/day. the animals were decapitated at the second and sixth weeks postcrush. Soleus and medial gastrocnemius were immediately excised to be weighed. Type I and Ⅱ fibers of the muscles were differentiated by m-ATPase (pH 9.4) stain, and fiber diameters were evaluated. The results were as follows: 1) the weight of the soleus and medial gastrocnemius muscles showed a tendency to increase in both the denervation-exercised groups compared to the denervated groups. 2) In the 2-week denervation-exercised group, type Ⅱfiber diameter of soleus and type Ⅰfiber diameter of medial gastrocnemius were increased significantly compared to the denervated control group. 3) In the 6-week denervated-exercised group, type Ⅰ fiber diameter of soleus and type Ⅱ fiber diameter of medial gastrocnemius were hypertrophied significantly compared to sham-denervated group. The results of this study suggested that treadmill exercise partially prevented denervation atrophy in the soleus and medial gastrocnemius of the rat.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Sciatic nerve injury Denervated muscle atrophy Exercise