전침자극과 트레드밀운동이 허혈성 뇌졸중 백서모델의 근위축 및 BDNF 발현에 미치는 영향

• 영문명: Effects of Electroacupuncture and Treadmill Exercise on Muscle Atrophy and BDNF on the Ischemic Stroke Model of Rats
• 발행기관: 한국전문물리치료학회
• 저자명: 유영대(Young-dae Yoo) 민순규(Soon-gyu Min) 김기도(Gi-do Kim) 김계엽(Gye-yeop Kim) 심재환(Jae-hwan Shim)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제14권 제1호, 1~10쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2007.03.31

영문 초록

This study was designed to examine the effects of electroacupuncture and treadmill exercise on the improvement of muscle atrophy and Brain-Derived Neurotrophic Factor (BDNF) expression in an ischemic stroke model induced by middle cerebral artery occlusion. This study selected 120 Sprangue-Dawley rats, divided them into six groups, and assigned 5 rats to each group. Experiments were conducted for 1, 3 days and 1, 8 weeks, respectively. In each group, changes in weight of muscle and relative muscle of tibialis anterior muscle, histologic observations, and BDNF expression were observed and analyzed. For the changes in muscle weight of unaffected and affected sides of tibialis anterior, muscle atrophy was expressed in an affected side 3 days after ischemic stroke was induced. There was a statistically significant difference in Group Ⅵ 1 and 8 weeks after ischemic stroke was induced, compared to Group Ⅱ (p<.05). For the changes in relative muscle weight of unaffected and affected sides of tibial anterior muscle, there was significant decrease in each group 3 days after ischemic stroke was induced, compared to Group Ⅰ, while there was a statistically significant increase in Group Ⅵ 1 week after ischemic stroke was induced, compared to Group Ⅱ (p<.05). For neurologic exercise behavior test, Group Ⅵ generally had the highest score, compared to other groups. The results of the behavior test suggests that 8 weeks after ischemic stroke was induced, Group Ⅵ improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, thus indicating a similar state of muscle fiber and brain tissue in Group Ⅰ. In immunohistochemical observations, Group 1 week showed increase in BDNF. Based on these results, electroacupuncture and treadmill exercise may improve muscle atrophy and change in BDNF expression of ischemic stroke rats and contribute to the improvement of exercise function.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Brain-Derived Neurotrophic Factor (BDNF) Electroacupuncture Ischemic stroke Muscle atrophy Treadmill exercise